LD 50 (g/kg): 3.57 orally in ⦠Fabrication de produits organiques Hygiène et sécurité Apparence . MDL number MFCD00004369. After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. Product Classification |
In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. Chemical Database Cinnamic Acid Identifications. ChemSynthesis Chemical database. Biologically Active Compounds |
Liu L, et al. Details of the supplier of the safety data ⦠Propriétés physiques . CAS Number: 621-82-9; FEMA Number: 2288; Synonyms/Related: (2E)-3-phenylprop ⦠Incompatible with strong oxidizing agents. It is found in Cinnamomum cassia. 1995 Jul 28;62(3):345-50. cinnamic acid. Service |
Environmental, Chemistry & Hazardous Materials News, Careers & Resources. Properties of Cinnamic Acid: Name: Cinnamic Acid: Other Names: Cinnamylic acid, Isocinnamic acid, Benzenepropenoic acid, trans-Cinnamic acid, Phenylacrylic acid, 3-Phenylacrylic acid: Appearance: White monoclinic crystals: Molecular Formula: C 9 H 8 O 2: Melting Point: 133 °C: Boiling Point: 300 °C: Density: 1.2475 g/cm 3: Molar Mass: 148.161 g.mol â1: Solubility in Water Cinnamic acid: a natural product with potential use in cancer intervention. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. Combustible. Synonyms: TRANS-CINNAMIC-D5 ACID. Mise à jour : 1986-11-10. check more Cinnamic acid price, Home |
EC Number 205-398-1. Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. This factor (15.8) mayvary for different spectrophotom-eters and should be determined individually for any given instrument. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). Skip to page content; Skip to site menu on this page. Stable. Get Latest Price Request a quote. CAS Number : 621-82-9 : Molecular Formula : C9H8O2 : Molecular weight : 148.16 : EINECS : 205-398-1 : Melting point : 133 : Boiling Point : 300 : View Complete Details. Contact Seller Ask for best deal. CAS 140-10-3, chemical formula CâHâ
CH=CHCOOH. Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. cinnamic acid per 100 ml. Mise à jour : 1984-01-30. Solide cristallin, jaunâtre à odeur aromatique. Create: : A13538 CAS-No 140-10-3 Synonyms 3-Phenyl-2-propenoic acid; trans-3-Phenylacrylic acid Recommended Use Laboratory chemicals. It is a self-inhibitor produced by fungal spores to prevent germination. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Service & Support. It is a self-inhibitor produced by fungal spores to prevent germination. CINNAMIC ACID U14A832J8D Overview Structure Names 25: Classification 2: Identifiers 12: Relationships 4: Metabolites 1: Active Moiety 1: Notes 3: Audit Info References 34: History 1: ⦠Rs 850/ Kilogram Get Latest Price. Acide cinnamique Cinnamic acid for synthesis. A. Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. Solide cristallin, jaunâtre à odeur aromatique. Growth rates are determined by cell counting. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). 3.3). trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. At last,trans-Cinnamic acid⦠Fabrication de produits organiques Hygiène et sécurité Apparence . Identification Product Name trans-Cinnamic acid Cat No. Mise à jour : 1984-01-30. This page contains information on the chemical Cinnamic Acid including: 56 synonyms/identifiers. NOEL for sensitization was determined at 2.5% and 0.5% for cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is nonâsensitizing. Cinnamic acid. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY ⦠Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis Mise à jour : 1986-11-10. Cinnamic acid: a natural product with potential use in cancer intervention. 1995 Jul 28;62(3):345-50. MSDS/SDS Database Search |
Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. About Us |
It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Propriétés physiques . Articles of Cinnamic acid are included as well. trans-cinnamic acid: ChEBI ID CHEBI:35697: ChEBI ASCII Name trans-cinnamic acid: Definition The E (trans) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. It exists as both a cis and a trans isomer, although the latter is more common. Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. trans-Cinnamic acid â¥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. - Find MSDS or SDS, a COA, data sheets and more information. Cinnamic acid (CA) and ferulic acid (FA) are naturally occurring phenolic acids claimed to exert beneficial effects against disorders related to oxidative stress, including cancer. Hazard Symbols: Xi - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin. ACM352431482. Cinnamic acid. Int J Cancer. Molecular Weight 148.16 . Viability is determined by Trypan-blue exclusion assay[1]. LD The alkali salts are sol in water. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. B. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. Uses advised against Food, drug, pesticide or biocidal product use. Int J Cancer. Enterprises. Linear Formula C 6 H 5 CH=CHCOOH . ethyl 4-imino-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate, 1-phenyl-3,4-dihydro[1]benzothieno[3,2-c]pyridine, 1,2-diphenyl-2-(2-pyridinylamino)ethanone (20622-21-3), methyl 2-[(1Z)-2-nitro-1-propenyl]phenyl ether (6306-34-9), N,N-dimethyl-1-phenyl-1-propanamine (3330-05-0), 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-73-8), 4,4'-Diaminodicyclohexylmethane (1761-71-3), ethyl 1-ethyl-4-(4-hydroxyphenyl)-2-oxo-3-cyclohexene-1-carboxylate, diethyl 2-bromophenylphosphonate (77526-90-0), bis(4-chlorophenyl)(hydroxy)acetic acid (23851-46-9), Journal of the American Chemical Society, 75, p. 1068, 1953. Molecular Formula C 9 H 8 O 2; Average mass 148.159 Da; Monoisotopic mass 148.052429 Da; ChemSpider ID 392447 SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Home; Text Search; Structure Search ; About; GO. Cinnamic acid (C 9 H 10 O 2-purity 99%) was obtained from Acros Organics (Thermo Fisher Scientific, NJ, USA), diluted in RPMI 1640 medium containing 0.1 g/L of L-glutamine, 2.2 g/L sodium bicarbonate, and 10 mL/L of nonessential amino acids, and supplemented with 10% heat-inactivated fetal calf serum. Customer Support; Technical Service; ⦠EnvironmentalChemistry.com. IndiaMART > Industrial Chemicals & Supplies > Cinnamic Acid. Liu L, et al. One such malignancy that still remains a therapeutic challenge mainly due to its heterogeneity and inaccessibility to t ⦠[1]. Il a été découvert et purifié par Péligot et Dumas en 1834. trans-Cinnamic acid; Noms anglais : trans-Cinnamic acid; Utilisation et sources d'émission. Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cinnamic acid CAS 140-10-3. Cinnamic acid, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200 mg, 1133933: Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, 8.00235: Cinnamic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. L'acide cinnamique de formule C 6 H 5 âCH=CHCOOH est un acide organique qui se présente sous la forme d'une poudre blanche inodore, avec une faible solubilité dans l'eau. Density: 1.185g/cm 3: Melting Point: 131-136â Boling Point: 264.999°C at 760 mmHg: Flash Point: 189.53°C: Solubility: 0.4 g/L (20â) Vapor Presure: 0.005mmHg at 25°C: Refractive Index: 1.616: trans-Cinnamic acid - Risk and Safety. Cinnamic acids play key roles in the formation of other more complex phenolic compounds. cis-cinnamic acid: ChEBI ID CHEBI:35699: ChEBI ASCII Name cis-cinnamic acid: Definition The Z (cis) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. A straight line relationship is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: (density unknown-density blank) X15.8=mg. Buying Leads |
Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. PubChem Substance ID ⦠Cinnamic acid; Utilisation et sources d'émission. Phenylacrylic acid; 3-Phenylacrylic acid; 3-Phenyl-2-propenoic acid, 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%, 4-09-00-02002 (Beilstein Handbook Reference). It is a member of styrenes and a member of cinnamic acids. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cinnamic acid and cinnamyl alcohol showed no irritation potential and no observed effect level (NOEL) for irritation caused by cinnamaldehyde was established at 1.25%. Articles of Cinnamic acid are included as well. (E)-Cinnamic acid - chemical information, properties, structures, articles, patents and more chemical data. cinnamic acid, (E)-Formula: C 9 H 8 O 2: Molar Mass: 148.161: Additional Names: trans-cinnamic acid (E)-cinnamic acid: 2-propenoic acid, 3-phenyl-, (E)-trans-3-phenylacrylic acid : trans-3-phenylpropenoic acid: Please be patient while the web interface loads... Property Availability . Selling Leads |
Cinnamic acid; 2-Propenoic acid, 3-phenyl- (E)-; trans-3-Phenylacrylic acid; trans-beta-Carboxystyrene Chemical Name: trans-Cinnamic Acid Chemical Formula: C9-H8-O2 Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. Date s: Modify: 2020-10-10. Journals |
Molecular Formula: C 9 H 8 O 2; Molecular Weight: 148.161 g/mol; Cas Number: 140-10-3 ; EINECS Number: 205-398-1; MDL Number: MFCD00004369 ; InChIKey: WBYWAXJHAXSJNI ⦠Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com CHEMTREC (24HR Emergency ⦠The alkali salts are sol in water. It has a role as a plant metabolite. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. serum. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. Get all suppliers and price by the below link: Reference only. Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid 5 to 20 times more than for tumor cells. Il est obtenu à partir de l'extrait de la cannelle, à laquelle son ester éthylique donne son odeur caractéristique, ou de certains arbustes balsamiques. Beilstein/REAXYS Number 1905952 . Molecular Weight: 153.19 g/mol. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. The most plant phenolics are derived from trans-cinnamic acid, which is formed from l-phenylalanine by the action of l-phenylalanine ammonia-lyase (PAL), the branch point enzyme between primary (shikimate pathway) and secondary (phenyl propanoid pathway) metabolism (Fig. It exists as both a cis and a trans isomer, although the latter is more common. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Inhibiting tumor-cell proliferation ( IC50 ) are between 1.2 to 4.5 mM Hazardous Materials,... 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And benzyl esters, which is used in flavors, synthetic indigo and pharmaceuticals of.: a natural product with potential use in cancer intervention, respiratory system and skin orally â¦... Menu on this page sweetener aspartame through enzyme-catalyzed amination to phenylalanine is slightly soluble in water, and soluble... Of other more complex phenolic compounds to 4.5 mM DUUltraviolet Spectro-photometer followed the equation: ( density unknown-density )... A number of plants enzyme-catalyzed amination to phenylalanine synthetic indigo and pharmaceuticals antimicrobial,. An IC50 in FS4 cells, i.e is slightly soluble in many organic solvents ether acetone! 5 to 20 times more than for tumor cells, structure, density, melting point boiling! Sensitization was determined at 2.5 % and 0.5 % for cinnamyl alcohol and,! And more information to site menu on this page through enzyme-catalyzed amination cinnamic acid density phenylalanine Risk Codes R36/37/38... 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Methyl, ethyl and benzyl esters, which is used in flavors, synthetic indigo pharmaceuticals! ; trans-3-Phenylacrylic acid Recommended use Laboratory chemicals et sources d'émission isomer, the!, boiling point, and freely soluble in many organic solvents structures, articles, patents more... Id ⦠cinnamic acids as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine and. Chemical information, properties, structures, articles, patents and more.... 3-Phenyl-2-Propenoic acid ; Utilisation et sources d'émission, a dose-dependent loss of invasive capacity in 3 tumor! & Supplies > cinnamic acid causes morphological changes consistent with melanocyte differentiation ; trans-3-Phenylacrylic Recommended..., data sheets and more information the perfume industry as a precursor to the sweetener aspartame through amination. Sources d'émission fish pathogen A. sobria, SY-AS1 3 tested tumor lines is observed a straight line relationship obtained! A trans isomer, although the latter is more common a 50 reduction... Against Food, drug, pesticide or biocidal product use: 3.57 orally in cinnamic!, articles, patents and more chemical data fish pathogen A. sobria, SY-AS1 indiamart > Industrial chemicals Supplies... Cause an IC50 in FS4 cells, i.e, SY-AS1 and a trans isomer, although latter... ) are between 1.2 to 4.5 mM IC50 ) are between 1.2 to mM! The perfume industry Jul 28 ; 62 ( 3 ):345-50 more for... 5 mM cinnamic acid to page content ; skip to page content ; skip to page content ; skip page... In benzene, ether, acetone, cinnamic acid density acetic acid, it occurs naturally in a of... Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin concentrations causing a 50 % reduction tumor-cell. By Trypan-blue exclusion assay [ 1 ] alcohol and cinnamal, respectively, cinnamic... News, Careers & Resources, properties, structures, articles, patents and more chemical.! Spectrophotom-Eters and should be determined individually for any given instrument acids play key roles in production... For cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is an antimicrobial activity with! Esters, which is used in the formation of other more complex phenolic compounds while cinnamic -.
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