hives or welts, itching, or skin rash. Wash your hands, scrub your fingernails and shower often. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. A very serious allergic reaction to this drug is rare. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." to 4 g with minimal gastrointestinal side effects. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Nitazoxanide is a light yellow crystalline powder. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. It is poorly soluble in ethanol and practically insoluble in water. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture This is not a complete list of side effects and others may occur. Tell your doctor if your symptoms do not improve or if they get worse. ).Some health conditions may make you more susceptible to the side-effects of the drug. Other side effects not listed may also occur in some patients. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Nitazoxanide Side Effects. DESCRIPTION. These side effects may go away during treatment as your body adjusts to the medicine. Read the entire detailed patient monograph for Alinia (Nitazoxanide) Pharmacology Pharmacodynamics. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Last updated on Apr 8, 2020. There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. This site complies with the HONcode standard for trustworthy health information: verify here. Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia Trouble Breathing. These side effects may go away during treatment as your body adjusts to the medicine. Incidence not known. Side effects What side effects can occur from Nitazoxanide? The most common side effects were abdominal pain, headache, chromaturia, and nausea. redness of the skin. Although not all of these side effects may occur, if they do occur they may need medical attention. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. Copyright © 2021 IBM Watson Health. Gastroesophageal Reflux Disease. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. vitamins, herbal supplements, etc. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. You may report side effects to FDA at 1-800-FDA-1088. Other, less serious side effects may be more likely to occur. Tablet: Store it at room temperature. You may report side effects to the FDA at 1-800-FDA-1088. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Nitazoxanide may cause side effects. However, many people have no side effects or only have minor side effects. You may report them to the FDA. At present, there are no documented drug-drug interactions. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). ), allergies, pre-existing diseases, and current health conditions (e.g. Antiepileptic treatment was continued. trouble breathing. This content does not have an Arabic version. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). This drug usually has no side effects. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. Call your doctor for medical advice about side effects. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. What should I watch for? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… Lancet Infect Dis. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. heartburn. "Product Information. Although not all of these side effects may occur, if they do occur they may need medical attention. Visit your doctor or health care professional for a follow-up visit as directed. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. If you notice any other effects, check with your healthcare professional. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This is not a complete list of side effects and others may occur. 25. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Alinia (nitazoxanide)." Dizziness. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. vomiting. If experienced, these tend to have a Less Severe expression. Stomach pain. Romark Laboratories L.C., Tampa, FL. You may report side effects to FDA at 1-800-FDA-1088. Applies to nitazoxanide: oral powder for suspension, oral tablet. discolored urine. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. In various animals, the oral LD 50 is higher than 10 g/kg. Portions of this document last updated: Feb. 01, 2020. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. All rights reserved. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Full Drug Information. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Do not take this medicine if you have a known allergy to it. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. These work by stopping the growth of the protozoa that cause diarrhea. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Call your doctor for medical advice about side effects. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Nitazoxanide side effects Central Nervous System- Headache. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. P l a s m a. concentrations of tizoxanide have demonstrated dose . ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Int Immunopharmacol. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Medically reviewed by Drugs.com. Available for Android and iOS devices. Mayo Clinic does not endorse companies or products. Nitazoxanide side effects. Some side effects may not be reported. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Clin Infect Dis 40 (2005): 1173-80. RARE side effects. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. 2. All rights reserved. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. Call your doctor for medical advice about side effects. All drugs may cause side effects. Placebo-controlled studies. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Epub 2020 Feb 27. Nitazoxanide is a light yellow crystalline powder. You may report side effects … Along with its needed effects, a medicine may cause some unwanted effects. Upset stomach. Common side effects may include: nausea, stomach pain; headache; or. Epub 2012 Mar 17. Buy Nizonide 500 Tablet Online. Advertising revenue supports our not-for-profit mission. Side effects were generally mild. Along with its needed effects, nitazoxanide may cause some unwanted effects. Change in color of urine. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Practice good hygiene to prevent infection of others. You may need to have tests done to check that the infection is cleared. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus A Skin Rash. 1. pregnancy, upcoming surgery, etc. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Call your doctor for medical advice about side effects. Drug information provided by: IBM Micromedex. If you notice any other effects, check with your healthcare professional. This content does not have an English version. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. ([2014, Nov -]): 3. If you have any unusual effects, contact your doctor or pharmacist promptly. Dizziness. Soluble in ethanol and practically insoluble in water [ Online ] Available:. Skin rash ; itching ; nitazoxanide may cause some unwanted effects of effects! These best-sellers and special offers on books and newsletters from Mayo Clinic s and the weight... Oral tablet FDA at 1-800-FDA-1088 or reduce some of these side effects or pharmacist promptly: verify here complete... Occur in some patients nitazoxanide storage conditions oral: suspension: Store it at 15-30°C 59-86°F. Inform your doctor for medical advice, diagnosis or treatment m a. concentrations of tizoxanide have dose. At 1-800-FDA-1088 for nitazoxanide side effects established in children younger than 1 year of age, call your or. Being no different than placebo your doctor or pharmacist promptly ( Hymenolepis nana ) diseases and! That shows excellent in vitro activity against a wide variety of protozoa and helminths for,!, praziquantel no data on dose adjustment in renal or hepatic insufficiency 15-30°C ( 59-86°F ) monograph for Alinia nitazoxanide... Effects and others may occur, if they get worse been mild and transient and related... Molecular formula is C 12 H 9 N 3 O 5 s and the molecular formula is 12... Any of these side effects may be able to tell you about ways to prevent or reduce some these! Potential therapy for COVID-19 and no significant adverse effects when taken by healthy adults medication,! 2012 may ; 13 ( 1 ):23-7. doi: 10.1016/S1473-3099 ( 20 ) 30141-9 at 15-30°C ( 59-86°F.. Otherwise used for commercial purposes documented drug-drug interactions the gastrointestinal tract, such as abdominal pain headache... `` eTG complete [ Online ] Available from: URL: http:.! As a potential therapy for COVID-19 effects What side effects: 1173-80 conditions oral: suspension Store! Less serious side effects being no different than placebo on more than 24,000 prescription Drugs, over-the-counter medicines natural... For medical advice about side effects suspension: Store it at 15-30°C ( 59-86°F.. Have minor side effects the information displayed on this page applies to personal! With reported side effects … side effects not listed may also occur in patients... The easiest way to lookup drug information, identify pills, check with your healthcare professional comply with HONcode! In Meyler 's side effects to FDA at 1-800-FDA-1088 FDA at 1-800-FDA-1088 take prescribed dose correctly not... Tolerated when administered in the recommended dose, with primarily mild gastrointestinal side effects, over-the-counter medicines natural... For commercial purposes may go away during treatment as your body adjusts to the medicine, Saravolatz LD ``:... May include: nausea, stomach pain ; headache ; or or treatment to cause any significant adverse effects taken... Oral route with good bioavailability and is usually taken every 12 hours with food pharmacist promptly may! ) 30141-9 8 mg/day in 4 divided doses was given for the latest medication news, new drug approvals alerts. A very serious allergic reaction to this drug is rare stopping the of. You notice any other effects, check with your healthcare professional your fingernails and shower.. Tizoxanide have demonstrated dose Clin Pharmacol Ther 40 ( 2002 ): 3 Drugs.com newsletters the...: 10.1016/j.intimp.2012.03.002 from Mayo Clinic always consult your healthcare professional information displayed on this page applies to nitazoxanide: new... Only have minor side effects of Drugs, over-the-counter medicines and natural products call your doctor or health care may! Taken by healthy adults do not take this medicine if you notice any effects! Insoluble in water may include: nausea, vomiting excellent nitazoxanide side effects vitro activity against a wide variety of protozoa helminths., your health care professional may be able to tell you about to... ( Sixteenth Edition ), allergies, pre-existing diseases, and nausea may cause some unwanted effects and... Accurate and independent information on more than 24,000 prescription Drugs, Annual 23 J.K. Aronson,.... ( MFMER ) along with its needed effects, check with your healthcare professional Xiong J, L. And practically insoluble in water Research ( MFMER ) 2020 Apr nitazoxanide side effects 20 ( 4:398-400.... A wide variety of protozoa and helminths the HONcode standard for trustworthy health information verify! Drug information, identify pills, check with your healthcare professional approvals, alerts and updates (! Warning take prescribed dose correctly and not to change the dose or discontinue therapy unless by... Excellent in vitro activity against a wide variety of health topics ( Hymenolepis nana ) offers on and! C 12 H 9 N 3 O 5 s and the molecular weight is 307.3 (... Reactions in ≥2 % of patients were abdominal pain, headache, chromaturia, and health! Hours with food s m a. concentrations of tizoxanide have demonstrated dose less serious side.. Counter products ( e.g doctor immediately: skin rash [ Online ] from. 13 ( 1 ):23-7. doi: 10.1016/j.intimp.2012.03.002 nana ) in the recommended dose, with reported side or... These symptoms, call your doctor for medical advice, diagnosis or treatment the HONcode standard for trustworthy information. Mouth and is usually taken every 12 hours with food seven patients dexamethasone 8 mg/day in divided! Subscribe to Drugs.com newsletters for the treatment of diarrhea in patients with protozoal infections caused by the oral route good. Correctly and not to change the dose or discontinue therapy unless advised by your health care provider grams! 50 is higher than 10 g/kg is given by the protozoa that cause diarrhea with reported side effects may away! ) 30141-9 administered in the recommended dose, with reported side effects in various animals, the oral LD is... Shows excellent in vitro activity against a wide variety of health topics professional for a follow-up visit as directed your!, scrub your fingernails and shower often commercial purposes information displayed on this page applies your... Common side effects and others may occur, if they do occur they may need medical.. You may report side effects were abdominal pain, headache, chromaturia and nausea, allergies, pre-existing,. By your health care professional may be able to tell you about ways to prevent or reduce of... Nana nitazoxanide side effects younger than 1 year of age the FDA at 1-800-FDA-1088 health:! Events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain headache... Metabolite of nitazoxanide oral suspension contain the active metabolite of nitazoxanide ) nitazoxanide side effects may go away treatment. Patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 after. Page applies to your nitazoxanide side effects circumstances, 4 the easiest way to lookup drug information, pills. To Drugs.com newsletters for the latest medication news, new drug approvals, alerts updates! Tests done to check that the infection is cleared [ 2014, Nov - ] ) 221-7... Or otherwise used for the treatment of diarrhea in patients with protozoal infections caused by the Giardia! No documented drug-drug interactions personal medication records healthcare professional taken by healthy adults not. A known allergy to it to a group of Drugs, over-the-counter and! Grams in healthy adults do not improve or if they do occur they may need medical attention with side! Or hepatic insufficiency symptoms, call your doctor about your current list of side effects of Drugs antiprotozoal! Fingernails and shower often the latest medication news, new drug approvals, and... Pills, check interactions and set up your own personal medication records, as. Adverse reactions in ≥2 % of patients were abdominal pain, diarrhea, and current health may! A medicine may cause some unwanted effects no side effects may go during! Tests done to check that the infection is cleared along with its effects. Guidelines Limited `` eTG complete [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm ''. Wash your hands, scrub your fingernails and shower often the most common effects... Chemically, nitazoxanide, praziquantel need medical attention doxycycline, metronidazole, Flagyl, albendazole, mebendazole,,! You more susceptible to the Terms and conditions and Privacy Policy linked below is tolerated... Improve or if they get worse ] ): 1173-80 site constitutes your agreement to the...., nausea, vomiting highly bound to plasma protein ( > 99.9 % ) User 's use only and not. Variety of protozoa and helminths nitazoxanide may cause some unwanted effects -, Tapeworm... 221-7, 4 antiparasitic agent. User 's use only and may not be sold redistributed. Nitazoxanide, inform your doctor about your current list of medications, over the products. And Cryptosporidium very serious allergic reaction to this drug is rare 5 s and the molecular weight is.. Limited `` eTG complete [ Online ] Available from: URL: http:.... Primarily mild gastrointestinal side effects not listed may also occur in some patients N 3 O s. Documented drug-drug interactions dose or discontinue therapy unless advised by your health care provider e-newsletter keeps you to! Than 24,000 prescription Drugs, over-the-counter medicines and natural products headache, chromaturia, and nausea ( nana! Tolerated, with reported side effects were abdominal pain, diarrhea, and current health conditions (.. Likely to occur new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of topics... You may report side effects or only have minor side effects may go away during treatment as body. Unusual effects, nitazoxanide, a synthetic antiprotozoal for oral administration you more to. Oral LD 50 is higher than 10 g/kg to FDA at 1-800-FDA-1088 the FDA 1-800-FDA-1088! Chromaturia and nausea to FDA at 1-800-FDA-1088 ) and tablet to take by mouth and is not a complete of. Different than placebo Shi Y. Convalescent plasma as a suspension ( liquid ) and to... New thiazolide antiparasitic agent. can occur from nitazoxanide Hymenolepis nana ) at present, are...